Worth the medicine?
Aleksi RaudasojaIn this substack, I translate the benefits and harms of medical treatments into plain numbers — which often reveal smaller benefits, and more unnecessary care, than you would think.
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
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| Issues | 10 | Founded | a year ago | Last Issue | 3 days ago |
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benefitsandharms.substack.comLatest Issues
"Cost-effective" does not mean "worth it"
In 1986, the government report that launched breast screening in the UK put its cost at £3,309 (today about £8,094) for each year of healthy life gained. The report argued the figure was in line with what the NHS already paid elsewhere. The...
We do not need evidence-based medicine 2.0
Some people regularly argue that evidence-based medicine is out of date or too strict an approach to reading medical evidence. For example, the evidence hierarchy is often criticized as too simplistic and as ignoring that types of evidence...
A more accurate way to look at cardiovascular benefits – delaying an event
When a statin is offered, the number you usually hear is a relative one: “this cuts your risk by about a quarter.” In a better consultation you get an absolute number instead: “with your risk profile, if a thousand people like you take a st...
Antibiotics for sinusitis: little or no benefit, some harms
According to a Cochrane review, from 100 adults with acute sinusitis who start antibiotics, about 5 will be cured at 1-2 weeks who would not yet be cured without the drug. About 13 of them will be harmed by it.
How sinusitis actually res...
Does Medical AI Automate Our Bias — or Inform Our Choices?
Ask a medical AI tool whether a 62-year-old with hypertension and hyperlipidemia should start a statin, and you will usually get an answer — well-sourced, fluent, citing the right trials. It will probably say yes or cite recent guidelines r...
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The writers behind this newsletter.
MD, PhD. I translate the benefits and harms of medical treatments into plain numbers — which often reveal smaller benefits, and more unnecessary care, than you would think.
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