All Things Tox
Brian H Mathison PhDExploring the interplay of fundamental physical principles with biological systems: genetics, biochemistry, pharmacology, physiology, pathology, toxicology, chemical carcinogenesis, and some legal implications. (energy, mass, space, and time)
| Platform |  | Pricing | Only free issues | Publishes | Twice weekly |
|---|---|---|---|---|---|
| Issues | 87 | Founded | 4 years ago | Last Issue | 12 days ago |
| Active | |||||
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brianhmathison.substack.comLatest Issues
Why I'm Here
The longer I have studied toxicology, the less interested I have become in certainty and the more interested I have become in understanding. I spent some time reflecting on my discourse and those reflections guided the creation of this grap...
Enzymatic and Non-Enzymatic Browning
Browning, enzymatic and non-enzymatic, has generated thousands of papers on food quality and toxicology. Food waste and spoilage sit at the center, polyphenol oxidase gets most of the attention, although it’s not the whole story. PPO oxidiz...
I’m a “PhD-Type”
While I’m not a fan of Rhonda Patrick (FoundMyFitness), her messaging, her style, or her influencer persona. Her latest smoothie-bananas commentary seems to have triggered a new round of banana-induced hysteria. But responses have been far...
The Erasure of “Harm”
Yesterday, July 14, 2026, the Trump administration finalized a rule first proposed in April 2025 that removes the regulatory definitions of “harm” from 50 C.F.R. §§ 17.3 and 222.102 without replacing them. Make no mistake: this is not a min...
The Dose Makes the Poison?
I’ve recently seen a lot of poor commentary on this dictum, so I thought I’d write a little again from my perspective.
“The dose makes the poison” is among the most quoted principles in toxicology, yet it is also one of the most misunderst...
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Authors
The writers behind this newsletter.
Father, husband, scientist, and toxicologist; BA in Biochemistry & Molecular Biology (UCSB); PhD in Environmental Toxicology (UCI); Inventor of Composite Transcription Factor Decoys.
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