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Prostate Cancer Secrets

Keith R. Holden, M.D.
Tens of paid subscribers

A physician with advanced prostate cancer, intolerant of standard therapy, shares surprising facts.

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Substack
PricingFreemiumPublishesWeekly
Issues83Founded5 years agoLast Issue9 days ago
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Artwork for Prostate Cancer Secrets

Latest Issues

My PSA Continues to Drop on Estradiol Patches - 078

It has been almost 12 weeks since I began estradiol patches for metastatic prostate cancer. Originally diagnosed in 2018 with locally advanced high-risk disease, I attempted conventional androgen deprivation therapy with goserelin (Zoladex)...

9 days ago
10
13

My Amazing Response to Estradiol Patches - 077

In just 29 days on estradiol 0.1 mg/day, four patches (tE2) changed twice weekly, I experienced the following:

PSA: 762 → 77.44 ng/mL (89.8% drop)

Testosterone: 518 → 60 ng/dL (88.4% drop) - Just above the castrate level of 50

  • *...
a month ago
17
21

My Latest PET Scan Results - 076

Before I tell you what my latest PET scan shows and what our plan is, I want to provide a quick reminder of how we got here.

April 5, 2018: Robotic radical prostatectomy - pathology - stage pT3b N1: Prostatic adenocarcinoma, Gleason score...

2 months ago
26
30

Turning The Lens On My Own DNA- 075

Before I move on to this newsletter topic, I want to update you on my “plan” regarding my rising PSA, which is 640 ng/mL as of March 5th. First of all, since the hospitalization I wrote about in my last newsletter, I am completely asymptoma...

4 months ago
12
5

I Was Hospitalized - 074

Before I tell you about my hospitalization, I need to tell you about my latest lab results.

On March 5, 2026, a comprehensive set of labs was normal except for a PSA of 640 ng/mL, a significant increase from my prior PSA of 395.90 ng/mL o...

5 months ago
20
16

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  • Keith R. Holden, M.D.

    I'm a physician with advanced prostate cancer, and science is not going to save me, so I'll have to do it myself. On this website and in this newsletter, I share that process along with some good and not-so-good things I've learned on this journey.

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