
A physician with advanced prostate cancer, intolerant of standard therapy, shares surprising facts.
| Platform | Pricing | Freemium | Publishes | Weekly | |
|---|---|---|---|---|---|
| Issues | 83 | Founded | 5 years ago | Last Issue | 9 days ago |
| Active | |||||

It has been almost 12 weeks since I began estradiol patches for metastatic prostate cancer. Originally diagnosed in 2018 with locally advanced high-risk disease, I attempted conventional androgen deprivation therapy with goserelin (Zoladex)...
In just 29 days on estradiol 0.1 mg/day, four patches (tE2) changed twice weekly, I experienced the following:
PSA: 762 → 77.44 ng/mL (89.8% drop)
Testosterone: 518 → 60 ng/dL (88.4% drop) - Just above the castrate level of 50
Before I tell you what my latest PET scan shows and what our plan is, I want to provide a quick reminder of how we got here.
April 5, 2018: Robotic radical prostatectomy - pathology - stage pT3b N1: Prostatic adenocarcinoma, Gleason score...
Before I move on to this newsletter topic, I want to update you on my “plan” regarding my rising PSA, which is 640 ng/mL as of March 5th. First of all, since the hospitalization I wrote about in my last newsletter, I am completely asymptoma...
Before I tell you about my hospitalization, I need to tell you about my latest lab results.
On March 5, 2026, a comprehensive set of labs was normal except for a PSA of 640 ng/mL, a significant increase from my prior PSA of 395.90 ng/mL o...
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The writers behind this newsletter.
I'm a physician with advanced prostate cancer, and science is not going to save me, so I'll have to do it myself. On this website and in this newsletter, I share that process along with some good and not-so-good things I've learned on this journey.
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