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Breakthrough

Samuel Hume, Andreas Huysman
Tens of paid subscribers

Research and analysis at the cutting edge of medicine.

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Substack
PricingFreemiumPublishesWeekly
Issues82Foundeda year agoLast Issue2 days ago
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Latest Issues

Every breakthrough in medicine in 2026... so far

In cancer, cardiovascular, autoimmunity, neurology, and metabolic medicine.

Three-quarters through the year, it’s time to look at what’s been achieved so far.

2 days ago
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Every first-in-class drug entering human trials in China this year

All 160 novel programs

I recently went to China for its biggest cancer conference (CSCO) and it’s clear there is a lot of novel science happening. The frontier of science is the first-in-human clinical trial — where a new drug is tested in...

11 days ago
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Do smaller biotechs generate better returns?

Yes they do (but only if backed by specialist investors).

Research from the quantitative hedge fund, Verdad, found that the segment of the biotech universe with the strongest returns is the smallest companies with the most specialist owner...

22 days ago
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Can we predict the results of clinical trials?

Dr. Thore Buergel is CEO at Pheiron, a company dedicated to predicting clinical trials using AI and big data.

We spoke about the data needed to do this, who the customer is, and about this year’s big trials (Novo Nordisk’s ZEUS trial, Nova...

a month ago
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A ranking of every biotech company

All 589 companies ranked, using Verdad’s quantitative investment model

The hedge fund, Verdad Capital, just published their quantitative model for biotech investing. They showed that companies with the highest scores have the best returns,...

a month ago
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Authors

The writers behind this newsletter.

  • Samuel Hume

    Doctor, scientist | Trying to speed up science and solve disease

  • Andreas Huysman

    PhD student investigating head and neck cancer immunology, MD, Science communicator

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