Letters from a Pharmacist
J Gamble, PhD RPhCritical drug evidence, distilled into practical pharmacotherapy insight.
| Platform |  | Pricing | Freemium | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 50 | Founded | a year ago | Last Issue | 19 days ago |
| Active | |||||
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jmgamble.substack.comLatest Issues
Interpreting composite endpoints in health research
Dear Reader,
Composite endpoints show up everywhere in modern clinical trials. Instead of hanging the results on a single outcome, researchers often bundle several clinically related events together and analyze them as one. That can be gen...
Three high-alert drugs in primary care
Dear Reader,
Many drugs have the potential to cause harm. Here is my list of the top 3 drug classes that are likely to cause harm in primary care.
I have selected these drugs from the Canadian High-Alert Medication List from ISMP Canada....
Why Insulin Rarely Works the Same Way Twice
Dear Reader,
One of the earliest lessons learners absorb about insulin is also one of the most misleading: that it behaves consistently. We teach starting doses, correction factors, and insulin‑to‑carbohydrate ratios as clean numbers that...
The LAMP Randomized Trial
The LAMP Randomized Trial. JAMA Intern Med 2026;186;(1):46-54
Dear Reader,
I am writing today about a unique GLP-1 receptor agonist trial called the LAMP trial, published in November of 2025 in JAMA Internal Medicine.1 This trial is novel...
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Authors
The writers behind this newsletter.
Pharmacoepidemiologist | Pharmacist | Clinical Associate Professor
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