Trial Files
TrialFilesFree monthly newsletter that summarizes the most significant, practice-changing randomized controlled trials, straight to your inbox.
| Platform |  | Pricing | Only free issues | Publishes | Weekly |
|---|---|---|---|---|---|
| Issues | 75 | Founded | 3 years ago | Last Issue | 23 days ago |
| Active | |||||
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trialfiles.substack.comLatest Issues
Trial Files: A Fourth Antidiabetic Drug vs. Metformin Uptitration, Immunomodulatory Agents During Infection in Patients with Rheumatic Disease, and Apixan vs. Rivaroxaban for VTE
How does adding a 4th antidiabetic agent compare to metformin uptitration?
Efficacy and safety of adding a fourth oral antidiabetic drug versus metformin dose escalation in patients with type 2 diabetes inadequately controlled on t...
Trial Files Throwback: Mitral-Valve Repair vs. Replacement, Romosozumab for Low Bone Mineral Density, and BP Target in Patients with Septic Shock
How do we know that replacement is not better than repair for MR?
Mitral-Valve Repair versus Replacement for Severe Ischemic Mitral Regurgitation (CTSN)
Acker MA et al. NEJM (January 2014)
Bottom Line: This randomized clinical...
Trial Files: Mifepristone for T2DM, Evolocumab for Patients Without Previous MI or Stroke, and Tenecteplase in Acute Central Retinal Artery Occlusion
Can cortisol-directed therapy improve glycemic control in patients with type 2 diabetes?
Inadequately Controlled Type 2 Diabetes and Hypercortisolism: Improved Glycemia With Mifepristone Treatment (CATALYST)
DeFronzo RA et al. Di...
Trial Files: Mediterranean Diet for IBS, Arterial Catheterization vs Noninvasive BP Monitoring in ICU Patients, and Beta-blockers in MI Without rEF
Should the Mediterranean diet be the first-line recommendation for IBS?
The Mediterranean Diet for Irritable Bowel Syndrome
Bamidele JO et al. Annals of Internal Medicine (October 2025)
Bottom Line: This randomized noninferiorit...
Trial Files Special Edition: Top 5 Trials of 2025
Don’t like to read? Listen to the Top 5 Trials via the The Rounds Table podcast:
SPOTIFY EPISODE 147
APPLE EPISODE 147
Should patients with provoked VTE receive more than 3 months of apixaban?
Apixaban for Extended Treatment of...
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Free biweekly newsletter for trainees and staff on General Internal Medicine at Sinai Health that summarizes the most significant, practice-changing randomized controlled trials, straight to your inbox.
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